Thromboembolic Events in Users of Warfarin Treated with Different Skeletal Muscle Relaxants.

ABSTRACT: Background and Objectives: Warfarin and a skeletal muscle relaxant are co-treatments in nearly a quarter-million annual United States (US) office visits. Despite international calls to minimize patient harm arising from anticoagulant drug interactions, scant data exist on clinical outcomes in real-world populations. We examined effects of concomitant use of warfarin and individual muscle relaxants on rates of hospitalization for thromboembolism among economically disadvantaged persons. Materials and Methods: Using 1999-2012 administrative data of four US state Medicaid programs, we conducted 16 retrospective self-controlled case series studies: half included concomitant users of warfarin + one of eight muscle relaxants; half included concomitant users of an inhaled corticoste

SUBMITTER: Leonard CE 

PROVIDER: S-EPMC9501796 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature