Metabolic Study of Tetra-PEG-Based Hydrogel after Pelvic Implantation in Rats.

ABSTRACT: In vivo metabolism of polyethylene glycol (PEG) hydrogels has rarely been studied. In this study, we prepared a chemically crosslinked hydrogel formulation using ¹⁴C-labeled tetra-armed poly (ethylene glycol) succinimidyl succinate (Tetra-PEG-SS) and ³H-labeled crosslinking agent for implantation into the pelvis of Sprague-Dawley (SD) rats. This radioactive labeling technique was used to investigate the radioactivity excretion rates in of feces and urine, the blood exposure time curve, and the radioactivity recovery rate in each tissue over time. We showed that the primary excretion route of the hydrogel was via urine (³H: about 86.4%, ¹⁴C: about 90.0%), with fewer portion through feces (³H: about 6.922%, ¹⁴C: about 8.16%).

SUBMITTER: Zuo B 

PROVIDER: S-EPMC9501824 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature