Barley Leaf Ameliorates Citrobacter rodentium-Induced Colitis through Preventive Effects.

ABSTRACT: The incidence and prevalence of inflammatory bowel disease (IBD) have been increasing globally and progressively in recent decades. Barley leaf (BL) is a nutritional supplement that is shown to have health-promoting effects on intestinal homeostasis. Our previous study demonstrated that BL could significantly attenuate Citrobacter rodentium (CR)-induced colitis, but whether it exerts a prophylactic or therapeutic effect remains elusive. In this study, we supplemented BL before or during CR infestation to investigate which way BL acts. The results showed that BL supplementation prior to infection significantly reduced the disease activity index (DAI) score, weight loss, colon shortening, colonic wall swelling, and transmissible murine colonic hyperplasia. It significantly reduced the

SUBMITTER: Feng Y 

PROVIDER: S-EPMC9502111 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature