Anti-Fibrotic Effect of SDF-1β Overexpression in Bleomycin-Injured Rat Lung.

ABSTRACT: Rational: Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease and is associated with high mortality due to a lack of effective treatment. Excessive deposition of the extracellular matrix by activated myofibroblasts in the alveolar space leads to scar formation that hinders gas exchange. Therefore, selectively removing activated myofibroblasts with the aim to repair and remodel fibrotic lungs is a promising approach. Stromal-derived growth factor (SDF-1) is known to stimulate cellular signals which attract stem cells to the site of injury for tissue repair and remodeling. Here, we investigate the effect of overexpression of SDF-1β on lung structure using the bleomycin-injured rat lung model. Methods: Intratracheal administration of bleomycin was perf

SUBMITTER: Fytianos K 

PROVIDER: S-EPMC9502331 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature