Insights into the degradation of diphenhydramine - An emerging SARS-CoV-2 medicine by UV/Sulfite.

ABSTRACT: As Diphenhydramine (DPH) has been considered as a drug to treat SARS-CoV-2, the degradation of DPH from water was investigated and evaluated in this study by adopting an advanced oxidation/advanced reduction process - the UV/sulfite process. The UV/sulfite system was able to eliminate DPH within 6 mins under UV_254nm and 1.0 mM sulfite. It was observed that the presence of NO3- , NO2- , Cl- , HCO3- , and SO42- anions in water can affect the performance of UV/Sulfite degradation system. The mechanism of UV/sulfite/anions was evaluated which the presence of NO3- in UV/sulfite process has revealed faster initial decay rate but lower final DPH removal. It was observed that the UV/Sulfite process was extremely sensitive to pH as the dissociation of ion species varied among pH. The rea

SUBMITTER: So HL 

PROVIDER: S-EPMC9502506 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature