Protein/Fiber Index Modulates Uremic Toxin Concentrations in Hemodialysis Patients.

ABSTRACT:

Background

Indoxyl sulfate (IS) and p-cresyl sulfate (PCS), two uremic toxins (UTs), are associated with increased mortality in patients with chronic kidney disease (CKD). These toxins are produced by the microbiota from the diet and excreted by the kidney. The purpose of this study was to analyze the effect of diet on IS and PCS concentration in hemodialysis (HD) patients.

Methods

We performed a prospective monocentric study using a seven-day diet record and determination of serum IS and PCS levels in HD patients. We tested the association between toxin concentrations and nutritional data.

Results

A total of 58/75 patients (77%) completed the diet record. Mean caloric intake was 22 ± 9.2 kcal/kg/day. The protein/fiber index was 4.9 ± 1.8. No correlation between IS or

SUBMITTER: Ebersolt M 

PROVIDER: S-EPMC9502511 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature