Forging a Functional Cure for HIV: Transcription Regulators and Inhibitors.

ABSTRACT: Current antiretroviral therapy (ART) increases the survival of HIV-infected individuals, yet it is not curative. The major barrier to finding a definitive cure for HIV is our inability to identify and eliminate long-lived cells containing the dormant provirus, termed viral reservoir. When ART is interrupted, the viral reservoir ensures heterogenous and stochastic HIV viral gene expression, which can reseed infection back to pre-ART levels. While strategies to permanently eradicate the virus have not yet provided significant success, recent work has focused on the management of this residual viral reservoir to effectively limit comorbidities associated with the ongoing viral transcription still observed during suppressive ART, as well as limit the need for daily ART. Our group has been at t

SUBMITTER: Mediouni S 

PROVIDER: S-EPMC9502519 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature