PACS-2 deficiency in tubular cells aggravates lipid-related kidney injury in diabetic kidney disease.

ABSTRACT:

Background

Lipid accumulation in tubular cells plays a key role in diabetic kidney disease (DKD). Targeting lipid metabolism disorders has clinical value in delaying the progression of DKD, but the precise mechanism by which molecules mediate lipid-related kidney injury remains unclear. Phosphofurin acidic cluster sorting protein 2 (PACS-2) is a multifunctional sorting protein that plays a role in lipid metabolism. This study determined the role of PACS-2 in lipid-related kidney injury in DKD.

Methods

Diabetes was induced by a high-fat diet combined with intraperitoneal injections of streptozotocin (HFD/STZ) in proximal tubule-specific knockout of Pacs-2 mice (PT-Pacs-2^-/- mice) and the control mice (Pacs-2^fl/fl mice). Transcriptomic analysis was perfor

SUBMITTER: Zhao C 

PROVIDER: S-EPMC9502582 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature