Large-scale analysis of protein crotonylation reveals its diverse functions in Pinellia ternata.

ABSTRACT:

Background

Pinellia ternata is an important traditional medicine in China, and its growth is regulated by the transcriptome or proteome. Lysine crotonylation, a newly identified and important type of posttranslational modification, plays a key role in many aspects of cell metabolism. However, little is known about its functions in Pinellia ternata.

Results

In this study, we generated a global crotonylome analysis of Pinellia ternata and examined its overlap with lysine succinylation. A total of 2106 crotonylated sites matched on 1006 proteins overlapping in three independent tests were identified, and we found three specific amino acids surrounding crotonylation sites in Pinellia ternata: K^crF, K***Y**K^cr and K^cr****R. Gene Ontology (GO) and

SUBMITTER: Guo W 

PROVIDER: S-EPMC9502611 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature