The Impact of Low Cardiac Output on Propofol Pharmacokinetics across Age Groups-An Investigation Using Physiologically Based Pharmacokinetic Modelling.

ABSTRACT:

Background

pathophysiological changes such as low cardiac output (LCO) impact pharmacokinetics, but its extent may be different throughout pediatrics compared to adults. Physiologically based pharmacokinetic (PBPK) modelling enables further exploration.

Methods

A validated propofol model was used to simulate the impact of LCO on propofol clearance across age groups using the PBPK platform, Simcyp^® (version 19). The hepatic and renal extraction ratio of propofol was then determined in all age groups. Subsequently, manual infusion dose explorations were conducted under LCO conditions, targeting a 3 µg/mL (80-125%) propofol concentration range.

Results

Both hepatic and renal extraction ratios increased from neonates, infants, children to adolescents and adults

SUBMITTER: Allegaert K 

PROVIDER: S-EPMC9502676 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature