Preparation and Characterization of Nifedipine-Loaded Dry Medium Internal-Phase Emulsions (Dry MIPEs) to Improve Cellular Permeability.

ABSTRACT: A nifedipine (NP) dry emulsion was fabricated by the adsorption of medium internal-phase emulsions (MIPEs). Simple homogenizers were first used to mix conventional liquid MIPEs, and then a microfluidizer was used to reduce the resulting emulsions' droplet sizes. The dry MIPEs (solid) were produced by adsorbing the emulsions onto solid carriers with a high surface area. The dry MIPEs were diluted in a simulated gastric fluid under gentle agitation to form emulsions. The diluted dry MIPEs were divided into three groups based on an NP content of 0.3%, 0.5%, and 0.7%, with sizes of 5026-5404 nm, 2583-3233 nm, and 1318-1618 nm in diameter, respectively. Powder X-ray diffraction (PXRD) measurements and differential scanning calorimetry (DSC) were used to characterize the physical properties of t

SUBMITTER: Tubtimsri S 

PROVIDER: S-EPMC9502710 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature