The Roles of Mitophagy and Autophagy in Ineffective Erythropoiesis in β-Thalassemia.

ABSTRACT: β-Thalassemia is one of the most common genetically inherited disorders worldwide, and it is characterized by defective β-globin chain synthesis leading to reduced or absent β-globin chains. The excess α-globin chains are the key factor leading to the death of differentiating erythroblasts in a process termed ineffective erythropoiesis, leading to anemia and associated complications in patients. The mechanism of ineffective erythropoiesis in β-thalassemia is complex and not fully understood. Autophagy is primarily known as a cell recycling mechanism in which old or dysfunctional proteins and organelles are digested to allow recycling of constituent elements. In late stage, erythropoiesis autophagy is involved in the removal of mitochondria as part of terminal differentiation. Several studi

SUBMITTER: Chaichompoo P 

PROVIDER: S-EPMC9502731 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature