Serum microRNAs in Systemic Sclerosis, Associations with Digital Vasculopathy and Lung Involvement

ABSTRACT: Abstract Background and aims: Systemic sclerosis (SSc) is an autoimmune, rare multisystem chronic disease that is still not well-understood aetiologically and is challenging diagnostically. In the literature, there are ever-increasing assumptions regarding the epigenetic mechanisms involved in SSc development; one of them is circulating microRNAs. Many of them regulate TLR pathways and are significant in autoimmune balance. The aim of this study was to determine profile expression of selected microRNAs in SSc patients, including miR-126, -132, -143, -145, -155, -181a, -29a and -3148, in comparison to healthy controls. Methods: Serum microRNAs were isolated from 45 patients with SSc and 57 healthy donors (HC). Additionally, SSc patients were considered in the aspect of disease subtype, incl

SUBMITTER: Wajda A 

PROVIDER: S-EPMC9503032 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature