The Ability of Biodegradable Thermosensitive Hydrogel Composite Calcium-Silicon-Based Bioactive Bone Cement in Promoting Osteogenesis and Repairing Rabbit Distal Femoral Defects.

ABSTRACT: Osteoporotic vertebral compression fractures are a global issue affecting the elderly population. To explore a new calcium silicate bone cement, polylactic acid (PLGA)-polyethylene glycol (PEG)-PLGA hydrogel was compounded with tricalcium silicate (C₃S)/dicalcium silicate (C₂S)/plaster of Paris (POP) to observe the hydration products and test physical and chemical properties. The cell compatibility and osteogenic capability were tested in vitro. The rabbit femoral condylar bone defect model was used to test its safety and effectiveness in vivo. The addition of hydrogel did not result in the formation of a new hydration product and significantly improved the injectability, anti-washout properties, and in vitro degradability of the bone cement. The cholecystokinin octap

SUBMITTER: Guo C 

PROVIDER: S-EPMC9503108 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature