Full-Length Genomic RNA of Foot-and-Mouth Disease Virus Is Infectious for Cattle by Injection.

ABSTRACT: Safe sample transport is of great importance for infectious diseases diagnostics. Various treatments and buffers are used to inactivate pathogens in diagnostic samples. At the same time, adequate sample preservation, particularly of nucleic acids, is essential to allow an accurate laboratory diagnosis. For viruses with single-stranded RNA genomes of positive polarity, such as foot-and-mouth disease virus (FMDV), however, naked full-length viral RNA can itself be infectious. In order to assess the risk of infection from inactivated FMDV samples, two animal experiments were performed. In the first trial, six cattle were injected with FMDV RNA (isolate A₂₂/IRQ/24/64) into the tongue epithelium. All animals developed clinical disease within two days and FMDV was reisolated from seru

SUBMITTER: Keck H 

PROVIDER: S-EPMC9503123 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature