Longitudinal disease-associated gut microbiome differences in infants with food protein-induced allergic proctocolitis.

ABSTRACT:

Background

Complex interactions between the gut microbiome and immune cells in infancy are thought to be part of the pathogenesis for the marked rise in pediatric allergic diseases, particularly food allergies. Food protein-induced allergic proctocolitis (FPIAP) is commonly the earliest recognized non-immunoglobulin E (IgE)-mediated food allergy in infancy and is associated with atopic dermatitis and subsequent IgE-mediated food allergy later in childhood. Yet, a large prospective longitudinal study of the microbiome of infants with FPIAP, including samples prior to symptom onset, has not been done.

Results

Here, we analyzed 954 longitudinal samples from 160 infants in a nested case-control study (81 who developed FPIAP and 79 matched controls) from 1 week to 1 year of age b

SUBMITTER: Martin VM 

PROVIDER: S-EPMC9503280 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature