Immunization with Genetically Modified Trypanosomes Provides Protection against Transmissible Spongiform Encephalopathies.

ABSTRACT: Transmissible spongiform encephalopathies are incurable neurodegenerative diseases, associated with the conversion of the physiological prion protein to its disease-associated counterpart. Even though immunization against transmissible spongiform encephalopathies has shown great potential, immune tolerance effects impede the use of active immunization protocols for successful prophylaxis. In this study, we evaluate the use of trypanosomes as biological platforms for the presentation of a prion antigenic peptide to the host immune system. Using the engineered trypanosomes in an immunization protocol without the use of adjuvants led to the development of a humoral immune response against the prion protein in wild type mice, without the appearance of adverse reactions. The immune reaction eli

SUBMITTER: Triller G 

PROVIDER: S-EPMC9503410 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature