Modelling Diabetic Cardiomyopathy: Using Human Stem Cell-Derived Cardiomyocytes to Complement Animal Models.
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ABSTRACT:
SUBMITTER: Purnama U
PROVIDER: S-EPMC9503602 | biostudies-literature | 2022 Sep
REPOSITORIES: biostudies-literature
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Modelling Diabetic Cardiomyopathy: Using Human Stem Cell-Derived Cardiomyocytes to Complement Animal Models.
Purnama Ujang U Castro-Guarda Marcos M Sahoo Om Saswat OS Carr Carolyn A CA
Metabolites 20220903 9
Diabetes is a global epidemic, with cardiovascular disease being the leading cause of death in diabetic patients. There is a pressing need for an in vitro model to aid understanding of the mechanisms driving diabetic heart disease, and to provide an accurate, reliable tool for drug testing. Human induced-pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have potential as a disease modelling tool. There are several factors that drive molecular changes inside cardiomyocytes contributing to ...[more]
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