Apprehending the NAD⁺-ADPr-Dependent Systems in the Virus World.

ABSTRACT: NAD⁺ and ADP-ribose (ADPr)-containing molecules are at the interface of virus-host conflicts across life encompassing RNA processing, restriction, lysogeny/dormancy and functional hijacking. We objectively defined the central components of the NAD⁺-ADPr networks involved in these conflicts and systematically surveyed 21,191 completely sequenced viral proteomes representative of all publicly available branches of the viral world to reconstruct a comprehensive picture of the viral NAD⁺-ADPr systems. These systems have been widely and repeatedly exploited by positive-strand RNA and DNA viruses, especially those with larger genomes and more intricate life-history strategies. We present evidence that ADP-ribosyltransferases (ARTs), ADPr-targeting Macro, NADAR an

SUBMITTER: Iyer LM 

PROVIDER: S-EPMC9503650 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature