Crosstalk between Ca²⁺ Signaling and Cancer Stemness: The Link to Cisplatin Resistance.

ABSTRACT: In the fight against cancer, therapeutic strategies using cisplatin are severely limited by the appearance of a resistant phenotype. While cisplatin is usually efficient at the beginning of the treatment, several patients endure resistance to this agent and face relapse. One of the reasons for this resistant phenotype is the emergence of a cell subpopulation known as cancer stem cells (CSCs). Due to their quiescent phenotype and self-renewal abilities, these cells have recently been recognized as a crucial field of investigation in cancer and treatment resistance. Changes in intracellular calcium (Ca²⁺) through Ca²⁺ channel activity are essential for many cellular processes such as proliferation, migration, differentiation, and survival in various cell types. It is no

SUBMITTER: Kouba S 

PROVIDER: S-EPMC9503744 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature