SARS-CoV-2 Monitoring in Wastewater Reveals Novel Variants and Biomarkers of Infection.

ABSTRACT: Wastewater-based epidemiology (WBE) is a popular tool for the early indication of community spread of infectious diseases. WBE emerged as an effective tool during the COVID-19 pandemic and has provided meaningful information to minimize the spread of infection. Here, we present a combination of analyses using the correlation of viral gene copies with clinical cases, sequencing of wastewater-derived RNA for the viral mutants, and correlative analyses of the viral gene copies with the bacterial biomarkers. Our study provides a unique platform for potentially using the WBE-derived results to predict the spread of COVID-19 and the emergence of new variants of concern. Further, we observed a strong correlation between the presence of SARS-CoV-2 and changes in the microbial community of wastewat

SUBMITTER: McGowan J 

PROVIDER: S-EPMC9503862 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature