An In Vitro Model for Characterization of Drug Permeability across the Tympanic Membrane.

ABSTRACT: Otic disorders, such as otitis media and hearing loss, affect a substantial portion of the global population. Despite this, oto-therapeutics, in particular those intended to treat hearing loss, have seen limited development and innovation. A significant factor to this is likely a result of the inherent costs and complexities of drug discovery and development. With in vitro 3D tissue models seeing increased utility for the rapid, high-throughput screening of drug candidates, it stands to reason that the field of otology could greatly benefit from such innovations. In this study, we propose and describe an in vitro 3D model, designed using a physiologically based approach, which we suggest can be used to estimate drug permeability across human tympanic membranes (TM). We characterize the per

SUBMITTER: Veit JGS 

PROVIDER: S-EPMC9503993 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature