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Distribution of Coronavirus Receptors in the Swine Respiratory and Intestinal Tract.

ABSTRACT: Coronaviruses use a broad range of host receptors for binding and cell entry, essential steps in establishing viral infections. This pilot study evaluated the overall distribution of angiotensin-converting enzyme 2 (ACE2), aminopeptidase N (APN), carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), and dipeptidyl peptidase 4 (DPP4) receptors in the pig respiratory and intestinal tract. All the receptors evaluated in this study were expressed and differentially distributed through the respiratory and intestinal tract. The presence and expression levels of these receptors could determine susceptibility to coronavirus infections. This study may have important implications for the development of research models and the assessment of the potential risk and introduction of novel coronaviruses into the swine population.

SUBMITTER: Nelli RK

PROVIDER: S-EPMC9504008 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature

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Distribution of Coronavirus Receptors in the Swine Respiratory and Intestinal Tract.

Nelli Rahul Kumar RK Roth James Allen JA Gimenez-Lirola Luis Gabriel LG

Veterinary sciences 20220913 9

Coronaviruses use a broad range of host receptors for binding and cell entry, essential steps in establishing viral infections. This pilot study evaluated the overall distribution of angiotensin-converting enzyme 2 (ACE2), aminopeptidase N (APN), carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), and dipeptidyl peptidase 4 (DPP4) receptors in the pig respiratory and intestinal tract. All the receptors evaluated in this study were expressed and differentially distributed through ...[more]

PMID: 36136717

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