GDF15 Contributes to Radioresistance by Mediating the EMT and Stemness of Breast Cancer Cells.

ABSTRACT: Radiotherapy is one of the conventional methods for the clinical treatment of breast cancer. However, radioresistance has an adverse effect on the prognosis of breast cancer patients after radiotherapy. In this study, using bioinformatic analysis of GSE59732 and GSE59733 datasets in the Gene Expression Omnibus (GEO) database together with the prognosis database of breast cancer patients after radiotherapy, the GDF15 gene was screened out to be related to the poor prognosis of breast cancer after radiotherapy. Compared with radiosensitive parental breast cancer cells, breast cancer cells with acquired radioresistance exhibited a high level of GDF15 expression and enhanced epithelial-to-mesenchymal transition (EMT) properties of migration and invasion, as well as obvious stem-like tra

SUBMITTER: Zhao X 

PROVIDER: S-EPMC9504016 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature