Preparation, Characterization and Study of the Dissociation of Naproxen from Its Chitosan Salt.

ABSTRACT: Salts of naproxen (NAP) with chitosan (CTS) and reticulated chitosan (CEP) were prepared under optimized conditions to maximize the yield of reaction. The objective was to evaluate the dissociation in water, which can guide studies of release of the drug from biopolymeric salts in pharmaceutical applications. Higher salification was found after 24 h of reaction at 60 °C in a molar ratio 1:1.05 (CTS:NAP, mol/mol), resulting in a degree of substitution (DS) of 17% according to ¹³C NMR, after neutralization of the -NH₂ group of the biopolymer by the carboxylic group of the drug. The presence of NAP salt is evidenced by FTIR bands related to the -NH₃⁺ group at 856 cm^-1, a decrease in crystallinity index in XRD diffractograms as well as cha

SUBMITTER: Medeiros RS 

PROVIDER: S-EPMC9504068 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature