Solid Nanomedicines of Nifurtimox and Benznidazole for the Oral Treatment of Chagas Disease.

ABSTRACT: Chagas disease (CD) is a parasitic zoonosis endemic in Central and South America affecting nearly 10 million people, with 100 million people at high risk of contracting the disease. Treatment is only effective when received at the early stages of the disease and it involved two drugs (nifurtimox (NFX) and benznidazole (BNZ)). Both treatments require multiple daily administrations of high doses, suffer from variable efficacy and insufficient efficacy in chronic CD, many side effects, and a very long duration of treatment that results in poor compliance, while combined available therapies that lead to reduced duration of treatment are not available and polypharmacy reduces compliance and increases the cost further. Here we present self-nanoemulsified drug delivery systems (SNEDDS) able to pr

SUBMITTER: Rolon M 

PROVIDER: S-EPMC9504116 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature