Strategies for Advanced Oncolytic Virotherapy: Current Technology Innovations and Clinical Approaches.

ABSTRACT: Oncolytic virotherapy is a type of nanomedicine with a dual antitumor mechanism. Viruses are engineered to selectively infect and lyse cancer cells directly, leading to the release of soluble antigens which induce systemic antitumor immunity. Representative drug Talimogene laherparepvec has showed promising therapeutic effects in advanced melanoma, especially when combined with immune checkpoint inhibitors with moderate adverse effects. Diverse viruses like herpes simplex virus, adenovirus, vaccina virus, and so on could be engineered as vectors to express different transgenic payloads, vastly expanding the therapeutic potential of oncolytic virotherapy. A number of related clinical trials are under way which are mainly focusing on solid tumors. Studies about further optimizing the genome

SUBMITTER: Ji Q 

PROVIDER: S-EPMC9504140 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature