Development and Characterization of an In Vitro Round Window Membrane Model for Drug Permeability Evaluations.

ABSTRACT: Hearing loss and balance disorders are highly common disorders, and the development of effective oto-therapeutics remains an area of intense research. Drug development and screening in the hearing research field heavily rely on the use of preclinical models with often ambiguous translational relevance. This often leads to failed advancement in the market of effective therapeutics. In this context, especially for inner ear-specific pathologies, the availability of an in vitro, physiologically relevant, round window membrane (RWM) model could enable rapid, high-throughput screening of potential topical drugs for inner ear and cochlear dysfunctions and could help accelerate the advancement to clinic and market of more viable drug candidates. In this study, we report the development and evalua

SUBMITTER: Singh R 

PROVIDER: S-EPMC9504332 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature