Different Approaches for the Profiling of Cancer Pathway-Related Genes in Glioblastoma Cells.

ABSTRACT: Deregulation of signalling pathways that regulate cell growth, survival, metabolism, and migration can frequently lead to the progression of cancer. Brain tumours are a large group of malignancies characterised by inter- and intratumoral heterogeneity, with glioblastoma (GBM) being the most aggressive and fatal. The present study aimed to characterise the expression of cancer pathway-related genes (n = 84) in glial tumour cell lines (A172, SW1088, and T98G). The transcriptomic data obtained by the qRT-PCR method were compared to different control groups, and the most appropriate control for subsequent interpretation of the obtained results was chosen. We analysed three widely used control groups (non-glioma cells) in glioblastoma research: Human Dermal Fibroblasts (HDFa), Normal Hum

SUBMITTER: Majercikova Z 

PROVIDER: S-EPMC9504477 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature