Analysis of the Contribution of Intrinsic Disorder in Shaping Potyvirus Genetic Diversity.

ABSTRACT: Intrinsically disordered regions (IDRs) are abundant in the proteome of RNA viruses. The multifunctional properties of these regions are widely documented and their structural flexibility is associated with the low constraint in their amino acid positions. Therefore, from an evolutionary stand point, these regions could have a greater propensity to accumulate non-synonymous mutations (NS) than highly structured regions (ORs, or 'ordered regions'). To address this hypothesis, we compared the distribution of non-synonymous mutations (NS), which we relate here to mutational robustness, in IDRs and ORs in the genome of potyviruses, a major genus of plant viruses. For this purpose, a simulation model was built and used to distinguish a possible selection phenomenon in the biological datasets fr

SUBMITTER: Lafforgue G 

PROVIDER: S-EPMC9504506 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature