Dosimetry of [²¹²Pb]VMT01, a MC1R-Targeted Alpha Therapeutic Compound, and Effect of Free ²⁰⁸Tl on Tissue Absorbed Doses.

ABSTRACT: [²¹²Pb]VMT01 is a melanocortin 1 receptor (MC1R) targeted theranostic ligand in clinical development for alpha particle therapy for melanoma. ²¹²Pb has an elementally matched gamma-emitting isotope ²⁰³Pb; thus, [²⁰³Pb]VMT01 can be used as an imaging surrogate for [²¹²Pb]VMT01. [²¹²Pb]VMT01 human serum stability studies have demonstrated retention of the ²¹²Bi daughter within the chelator following beta emission of parent ²¹²Pb. However, the subsequent alpha emission from the decay of ²¹²Bi into ²⁰⁸Tl results in the generation of free ²⁰⁸Tl. Due to the 10.64-hour half-life of ²¹²Pb, accumulation of free ²⁰⁸Tl in the injectate will occur. The goal of

SUBMITTER: Orcutt KD 

PROVIDER: S-EPMC9504749 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature