The Bovine Seminal Plasma Protein PDC-109 Possesses Pan-Antiviral Activity.

ABSTRACT: Mammalian seminal plasma contains a multitude of bioactive components, including lipids, glucose, mineral elements, metabolites, proteins, cytokines, and growth factors, with various functions during insemination and fertilization. The seminal plasma protein PDC-109 is one of the major soluble components of the bovine ejaculate and is crucially important for sperm motility, capacitation, and acrosome reaction. A hitherto underappreciated function of seminal plasma is its anti-microbial and antiviral activity, which may limit the sexual transmission of infectious diseases during intercourse. We have recently discovered that PDC-109 inhibits the membrane fusion activity of influenza virus particles and significantly impairs viral infections at micromolar concentrations. Here we investigated

SUBMITTER: Sperber HS 

PROVIDER: S-EPMC9504757 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature