A single-cell atlas of human and mouse white adipose tissue.

ABSTRACT: White adipose tissue, once regarded as morphologically and functionally bland, is now recognized to be dynamic, plastic and heterogenous, and is involved in a wide array of biological processes including energy homeostasis, glucose and lipid handling, blood pressure control and host defence¹. High-fat feeding and other metabolic stressors cause marked changes in adipose morphology, physiology and cellular composition¹, and alterations in adiposity are associated with insulin resistance, dyslipidemia and type 2 diabetes². Here we provide detailed cellular atlases of human and mouse subcutaneous and visceral white fat at single-cell resolution across a range of body weight. We identify subpopulations of adipocytes, adipose stem and progenitor cells, vascular

SUBMITTER: Emont MP 

PROVIDER: S-EPMC9504827 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature