Birth Weight and Early Postnatal Outcomes: Association with the Cord Blood Lipidome.

ABSTRACT: Being born small or large for gestational age (SGA and LGA, respectively), combined with suboptimal early postnatal outcomes, can entail future metabolic alterations. The exact mechanisms underlying such risks are not fully understood. Lipids are a highly diverse class of molecules that perform multiple structural and metabolic functions. Dysregulation of lipid metabolism underlies the onset and progression of many disorders leading to pathological states. The aim of this pilot study was to investigate the relationships between birth weight, early postnatal outcomes, and cord blood serum lipidomes. We performed a non-targeted lipidomics-based approach to ascertain differences in cord blood lipid species among SGA, LGA, and appropriate-for-GA (AGA) newborns. Moreover, we longitudinally asse

SUBMITTER: Gonzalez-Riano C 

PROVIDER: S-EPMC9505183 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature