Nitrostilbenes: Synthesis and Biological Evaluation as Potential Anti-Influenza Virus Agents.

ABSTRACT: Resveratrol (RSV) is a natural stilbene polyphenolic compound found in several plant species. It is characterized by antioxidant properties, and its role in controlling viral replication has been demonstrated for different viral infections. Despite its promising antiviral properties, RSV biological activity is limited by its low bioavailability and high metabolic rate. In this study, we optimized its structure by synthesizing new RSV derivatives that maintained the phenolic scaffold and contained different substitution patterns and evaluated their potential anti-influenza virus activity. The results showed that viral protein synthesis decreased 24 h post infection; particularly, the nitro-containing compounds strongly reduced viral replication. The molecules did not exert their antioxidant

SUBMITTER: De Angelis M 

PROVIDER: S-EPMC9505218 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature