Replication of Human Norovirus in Mice after Antibiotic-Mediated Intestinal Bacteria Depletion.

ABSTRACT: Human noroviruses (HuNoVs) are the main cause of acute gastroenteritis causing more than 50,000 deaths per year. Recent evidence shows that the gut microbiota plays a key role in enteric virus infectivity. In this context, we tested whether microbiota depletion or microbiota replacement with that of human individuals susceptible to HuNoVs infection could favor viral replication in mice. Four groups of mice (n = 5) were used, including a control group and three groups that were treated with antibiotics to eliminate the autochthonous intestinal microbiota. Two of the antibiotic-treated groups received fecal microbiota transplantation from a pool of feces from infants (age 1-3 months) or an auto-transplantation with mouse feces that obtained prior antibiotic treatment. The inoculation of the

SUBMITTER: Santiso-Bellon C 

PROVIDER: S-EPMC9505278 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature