Significant Enhancement of 5-Hydroxymethylfural Productivity from D-Fructose with SG(SiO₂) in Betaine:Glycerol-Water for Efficient Synthesis of Biobased 5-(Hydroxymethyl)furfurylamine.

ABSTRACT: 5-Hydroxymethyl-2-furfurylamine (5-HMFA) as an important 5-HMF derivative has been widely utilized in the manufacture of diuretics, antihypertensive drugs, preservatives and curing agents. In this work, an efficient chemoenzymatic route was constructed for producing 5-(hydroxymethyl)furfurylamine (5-HMFA) from biobased D-fructose in deep eutectic solvent Betaine:Glycerol-water. The introduction of Betaine:Glycerol could greatly promote the dehydration of D-fructose to 5-HMF and inhibit the secondary decomposition reactions of 5-HMF, compared with a single aqueous phase. D-Fructose (200 mM) could be catalyzed to 5-HMF (183.4 mM) at 91.7% yield by SG(SiO₂) (3 wt%) after 90 min in Betaine:Glycerol (20 wt%), and at 150 °C. E. coli AT exhibited excellent b

SUBMITTER: Xu D 

PROVIDER: S-EPMC9505363 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature