Mechanistic Role of Jak3 in Obesity-Associated Cognitive Impairments.

ABSTRACT:

Background and aims

A compromise in intestinal mucosal functions is associated with several chronic inflammatory diseases. Previously, we reported that obese humans have a reduced expression of intestinal Janus kinase-3 (Jak3), a non-receptor tyrosine kinase, and a deficiency of Jak3 in mice led to predisposition to obesity-associated metabolic syndrome. Since meta-analyses show cognitive impairment as co-morbidity of obesity, the present study demonstrates the mechanistic role of Jak3 in obesity associated cognitive impairment. Our data show that high-fat diet (HFD) suppresses Jak3 expression both in intestinal mucosa and in the brain of wild-type mice.

Methodology

Recapitulating these conditions using global (Jak3-KO) and intestinal epithelial cell-specific conditional (IE

SUBMITTER: Kumar P 

PROVIDER: S-EPMC9505565 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature