Higher Circulating Vitamin D Levels Are Associated With Decreased Migraine Risk: A Mendelian Randomization Study.

ABSTRACT:

Background

Evidence showed the supplementation of vitamin D might have beneficial effects for migraine patients. We aimed to investigate the causal effects of serum vitamin D levels on migraine risk using two-sample Mendelian randomization (MR) method.

Methods

A total of 184 independent genetic instruments for serum vitamin D levels were selected from a study in 417,580 Europeans from UK biobank. Six variants from an independent study were obtained to perform replication analysis. Summary-level data for migraine were obtained from three studies with 48,975 migraine cases, 28,852 migraine cases and 10,536 migraine cases, respectively.

Results

The estimated odds ratios (ORs) per standard deviation increase in circulating vitamin D levels based on the three migraine data

SUBMITTER: Niu PP 

PROVIDER: S-EPMC9505695 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature