In-Silico Molecular Modeling Studies to Identify Novel Potential Inhibitors of HPV E6 Protein.

ABSTRACT: The etiological agent of some anogenital tract cancers is infection with the high-risk human papillomavirus (HPV). Currently, prophylactic vaccines against HPV have been validated, but the presence of drug treatment directed against the infection and its oncogenic effects remain essential. Among the best drug targets, viral oncoprotein E6 has been identified as a key factor in cell immortalization and tumor progression in HPV-positive cells. E6, through interaction with the cellular ubiquitin ligase E6AP, can promote the degradation of p53, a tumor suppressor protein. Therefore, suppression of the creation of the E6-E6AP complex is one of the essential strategies to inhibit the survival and proliferation of infected cells. In the present study, we proposed an in-silico approach for the dis

SUBMITTER: Soumia M 

PROVIDER: S-EPMC9505724 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature