Chemistry and Bioactivity of the Deep-Water Antarctic Octocoral Alcyonium sp.

ABSTRACT: Chemical investigation of an Antarctic deep-water octocoral has led to the isolation of four new compounds, including three illudalane sesquiterpenoids (1-3) related to the alcyopterosins, a highly oxidized steroid, alcyosterone (5), and five known alcyopterosins (4, 6-9). The structures were established by extensive 1D and 2D NMR analyses, while 9 was verified by XRD. Alcyopterosins are unusual for their nitrate ester functionalization and have been characterized with cytotoxicity related to their DNA binding properties. Alcyopterosins V (3) and E (4) demonstrated single-digit micromolar activity against Clostridium difficile, an intestinal bacterium capable of causing severe diarrhea that is increasingly associated wit

SUBMITTER: Limon AD 

PROVIDER: S-EPMC9505732 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature