Prognostic stratification based on m⁵C regulators acts as a novel biomarker for immunotherapy in hepatocellular carcinoma.

ABSTRACT:

Background

Immunotherapy is a promising anti-cancer strategy in hepatocellular carcinoma (HCC). However, a limited number of patients can benefit from it. There are currently no reliable biomarkers available to find the potential beneficiaries. Methylcytosine (m⁵C) is crucial in HCC, but its role in forecasting clinical responses to immunotherapy has not been fully clarified.

Methods

In this study, we analyzed 371 HCC patients from The Cancer Genome Atlas (TCGA) database and investigated the expression of 18 m⁵C regulators. We selected 6 differentially expressed genes (DEGs) to construct a prognostic risk model as well as 2 m⁵C-related diagnostic models.

Results

The 1-, 3-, and 5-year area under the curve (AUC) of m⁵C scores

SUBMITTER: Liu P 

PROVIDER: S-EPMC9505913 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature