PH-Driven Intracellular Nano-to-Molecular Disassembly of Heterometallic [Au₂L₂]{Re₆Q₈} Colloids (L = PNNP Ligand; Q = S^2- or Se^2-).

ABSTRACT: The present work introduces a simple, electrostatically driven approach to engineered nanomaterial built from the highly cytotoxic [Au₂L₂]²⁺ complex (Au₂, L = 1,5-bis(p-tolyl)-3,7-bis(pyridine-2-yl)-1,5-diaza-3,7-diphosphacyclooctane (PNNP) ligand) and the pH-sensitive red-emitting [{Re₆Q₈}(OH)₆]^4- (Re₆-Q, Q = S^2- or Se^2-) cluster units. The protonation/deprotonation of the Re₆-Q unit is a prerequisite for the pH-triggered assembly of Au₂ and Re₆-Q into Au₂Re₆-Q colloids, exhibiting disassembly in acidic (pH = 4.5) conditions modeling a lysosomal environment. The counter-ion effect of polyethylenimine causes the rele

SUBMITTER: Faizullin B 

PROVIDER: S-EPMC9505965 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature