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Two Pairs of 7,7'-Cyclolignan Enantiomers with Anti-Inflammatory Activities from Perilla frutescens.


ABSTRACT: Perilla frutescens (L.) Britt. (Labiatae), a medicinal plant, has been widely used for the therapy of multiple diseases since about 1800 years ago. It has been demonstrated that the extracts of P. frutescens exert significant anti-inflammatory effects. In this research, two pairs of 7,7'-cyclolignan enantiomers, possessing a cyclobutane moiety, (+)/(-)-perfrancin [(+)/(-)-1] and (+)/(-)-magnosalin [(+)/(-)-2], were separated from P. frutescens leaves. The present study achieved the chiral separation and determined the absolute configuration of (±)-1 and (±)-2. Compounds (+)-1 and (-)-1 have notable anti-inflammatory effects by reducing the secretion of pro-inflammatory factors (NO, TNF-α and IL-6) and the expression of pro-inflammatory mediators (iNOS and COX-2). These findings indicate that cyclolignans are effective substances of P. frutescens with anti-inflammatory activity. The present study partially elucidates the mechanisms underlying the effects of P. frutescens.

SUBMITTER: Zuo J 

PROVIDER: S-EPMC9506341 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature

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Two Pairs of 7,7'-Cyclolignan Enantiomers with Anti-Inflammatory Activities from <i>Perilla frutescens</i>.

Zuo Jing J   Zhang Tian-Hao TH   Xiong Liang L   Huang Lu L   Peng Cheng C   Zhou Qin-Mei QM   Dai Ou O  

Molecules (Basel, Switzerland) 20220918 18


<i>Perilla frutescens</i> (L.) Britt. (Labiatae), a medicinal plant, has been widely used for the therapy of multiple diseases since about 1800 years ago. It has been demonstrated that the extracts of <i>P. frutescens</i> exert significant anti-inflammatory effects. In this research, two pairs of 7,7'-cyclolignan enantiomers, possessing a cyclobutane moiety, (+)/(-)-perfrancin [(+)/(-)-<b>1</b>] and (+)/(-)-magnosalin [(+)/(-)-<b>2</b>], were separated from <i>P. frutescens</i> leaves. The prese  ...[more]

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