Serum metabolomic analysis reveals several novel metabolites in association with excessive alcohol use - an exploratory study.

ABSTRACT: Appropriate screening tool for excessive alcohol use (EAU) is clinically important as it may help providers encourage early intervention and prevent adverse outcomes. We hypothesized that patients with excessive alcohol use will have distinct serum metabolites when compared to healthy controls. Serum metabolic profiling of 22 healthy controls and 147 patients with a history of EAU was performed. We employed seemingly unrelated regression to identify the unique metabolites and found 67 metabolites (out of 556), which were differentially expressed in patients with EAU. Sixteen metabolites belong to the sphingolipid metabolism, 13 belong to phospholipid metabolism, and the remaining 38 were metabolites of 25 different pathways. We also found 93 serum metabolites that were significantly associ

SUBMITTER: Liu D 

PROVIDER: S-EPMC9506418 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature