Excitatory and inhibitory effects of HCN channel modulation on excitability of layer V pyramidal cells.

ABSTRACT: Dendrites of cortical pyramidal cells are densely populated by hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, a.k.a. Ih channels. Ih channels are targeted by multiple neuromodulatory pathways, and thus are one of the key ion-channel populations regulating the pyramidal cell activity. Previous observations and theories attribute opposing effects of the Ih channels on neuronal excitability due to their mildly hyperpolarized reversal potential. These effects are difficult to measure experimentally due to the fine spatiotemporal landscape of the Ih activity in the dendrites, but computational models provide an efficient tool for studying this question in a reduced but generalizable setting. In this work, we build upon existing biophysically detailed models of thick-tufted

SUBMITTER: Maki-Marttunen T 

PROVIDER: S-EPMC9506642 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature