A computational model to explore how temporal stimulation patterns affect synapse plasticity.

ABSTRACT: Plasticity-related proteins (PRPs), which are synthesized in a synapse activation-dependent manner, are shared by multiple synapses to a limited spatial extent for a specific period. In addition, stimulated synapses can utilize shared PRPs through synaptic tagging and capture (STC). In particular, the phenomenon by which short-lived early long-term potentiation is transformed into long-lived late long-term potentiation using shared PRPs is called "late-associativity," which is the underlying principle of "cluster plasticity." We hypothesized that the competitive capture of PRPs by multiple synapses modulates late-associativity and affects the fate of each synapse in terms of whether it is integrated into a synapse cluster. We tested our hypothesis by developing a computational model to sim

SUBMITTER: Amano R 

PROVIDER: S-EPMC9506666 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature