Differentiation signals from glia are fine-tuned to set neuronal numbers during development.

ABSTRACT: Neural circuit formation and function require that diverse neurons are specified in appropriate numbers. Known strategies for controlling neuronal numbers involve regulating either cell proliferation or survival. We used the Drosophila visual system to probe how neuronal numbers are set. Photoreceptors from the eye-disc induce their target field, the lamina, such that for every unit eye there is a corresponding lamina unit (column). Although each column initially contains ~6 post-mitotic lamina precursors, only 5 differentiate into neurons, called L1-L5; the 'extra' precursor, which is invariantly positioned above the L5 neuron in each column, undergoes apoptosis. Here, we showed that a glial population called the outer chiasm giant glia (xg^O), which resides below the lam

SUBMITTER: Prasad AR 

PROVIDER: S-EPMC9507125 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature