Fibrodysplasia Ossificans Progressiva and Pregnancy: A Case Series and Review of the Literature.

ABSTRACT:

Objective

To evaluate maternal and fetal outcomes in pregnant patients with fibrodysplasia ossificans progressiva (FOP; OMIM#135100), an ultrarare genetic disorder characterized by progressive heterotopic ossification of soft tissues and cumulative disability.

Methods

This is a retrospective case series of three patients with FOP who were admitted to Grady Memorial Hospital in Atlanta, Georgia, from to February 2011 to July 2021.

Results

Three women delivered preterm infants at our institution. These cases posed unique anesthetic and obstetric technical challenges, particularly when securing the airway and performing cesarean delivery. Importantly, each patient received perioperative glucocorticoids for prevention of further heterotopic ossification.

Conclusion

SUBMITTER: Forrest AD 

PROVIDER: S-EPMC9507790 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature