Association between aerobic fitness and the functional connectome in patients with schizophrenia.

ABSTRACT:

Background

Schizophrenia is accompanied by widespread alterations in static functional connectivity associated with symptom severity and cognitive deficits. Improvements in aerobic fitness have been demonstrated to ameliorate symptomatology and cognition in people with schizophrenia, but the intermediary role of macroscale connectivity patterns remains unknown.

Objective

Therefore, we aim to explore the relation between aerobic fitness and the functional connectome in individuals with schizophrenia. Further, we investigate clinical and cognitive relevance of the identified fitness-connectivity links.

Methods

Patients diagnosed with schizophrenia were included in this cross-sectional resting-state fMRI analysis. Multilevel Bayesian partial correlations between aerobic

SUBMITTER: Roell L 

PROVIDER: S-EPMC9508005 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature